The Toon teenagers will face the defending champions at Whitley Park on Thursday, 18th September, with kick-off set at 3pm (BST).
The Magpies’ under-19s return to the competition in 2025/26, which will mirror the new format of the UEFA Champions League with an initial 36-team league phase.
They will, however, play just the first six parallel fixtures in the Youth League league phase, in contrast to the eight matches contested in the Champions League.
Newcastle's schedule can be found below, with details for future UEFA Youth League fixtures to be announced on newcastleunited.com in due course.
FC Barcelona
Union Saint-Gilloise
Benfica
Athletic Club
Olympique Marseille
Bayer Leverkusen